Table 2.
Summary questions presented in second online survey for interim prioritisation (50 in total)
| 1. | How can we optimise information giving for those at risk of or affected by pregnancy hypertension? |
| 2. | How can pregnancy hypertension (including pre-eclampsia) be prevented in a subsequent pregnancy? |
| 3. | What is the cause of pregnancy hypertension (including pre-eclampsia)? |
| 4. | What can be done prior to pregnancy to reduce the risk of pregnancy hypertension? |
| 5. | What is the best way to manage pre-eclampsia? |
| 6. | How can we provide better support for women with pregnancy hypertension and their families? |
| 7. | What is the best way to diagnose pre-eclampsia promptly? |
| 8. | What is the effectiveness and safety of antihypertensive agents at reducing blood pressure in women with pregnancy hypertension? |
| 9. | What are the long-term consequences of pre-eclampsia for the woman and baby? |
| 10. | What is the effectiveness and safety of pharmacological treatments once pre-eclampsia is diagnosed? |
| 11. | How does the placenta contribute to pre-eclampsia? |
| 12. | What is the optimal antihypertensive medication to use postnatally? |
| 13. | What is the best screening test for pre-eclampsia? |
| 14. | What are the optimum blood pressure thresholds (for initiation) and targets for antenatal antihypertensive treatment? |
| 15. | Is there a hereditary link in pre-eclampsia and are the risks different for daughters and sons after an affected pregnancy? |
| 16. | How can we predict complications of pregnancy hypertension (progression to pre-eclampsia)? |
| 17. | What is the optimal timing of delivery in women with pregnancy hypertension? |
| 18. | What interventions are effective and safe at reducing fetal growth restriction in women with pregnancy hypertension? |
| 19. | What are the long-term effects of pre-eclampsia on mental health? |
| 20. | Following pregnancy hypertension, what is the best way to prevent future long-term problems? |
| 21. | What are the educational needs of healthcare professionals managing women with pregnancy hypertension? |
| 22. | What are the fetal, infant and child outcomes in women taking antihypertensive agents? |
| 23. | How can we better prevent stillbirth in pre-eclampsia? |
| 24. | What are the optimum blood pressure thresholds (for initiation) and targets for postnatal antihypertensive treatment? |
| 25. | What prepregnancy management of women with chronic hypertension optimises pregnancy outcomes? |
| 26. | What is the optimal monitoring strategy for women before, during and after pregnancy hypertension (including in subsequent pregnancies)? |
| 27. | What are the risk factors for developing pregnancy hypertension and pre-eclampsia? |
| 28. | How can pregnancy hypertension (including pre-eclampsia) be prevented during a pregnancy? |
| 29. | What is the risk of pregnancy hypertension in a subsequent pregnancy? |
| 30. | What is the best test to predict pregnancy hypertension? |
| 31. | What methods are effective at measuring blood pressure in women with pregnancy hypertension (including self-monitoring, ambulatory, automated, manual)? |
| 32. | What is the paternal contribution to pre-eclampsia? |
| 33. | What are the characteristics of postpartum pre-eclampsia? |
| 34. | What is the safety of treatments for pregnancy hypertension for the fetus and infant? |
| 35. | What are the long-term effects of pre-eclampsia on cardiovascular disease for the woman and baby? |
| 36. | What are the long-term effects of pregnancy hypertension on subsequent maternal blood pressure? |
| 37. | What are the consequences of pregnancy hypertension on pre-eclampsia, birth weight and prematurity in that pregnancy? |
| 38. | What is the relationship between blood pressure in pregnancy and development of pregnancy hypertension? |
| 39. | What are the mechanisms for increased cardiovascular risk for a woman and her child? |
| 40. | What are the effects of lifestyle interventions (eg, diet, exercise) in reducing high blood pressure in pregnancy? |
| 41. | What are the short-term and long-term health implications for infants of women with pregnancy hypertension and can these be modified? |
| 42. | What are the long-term neurodevelopmental implications of pregnancy hypertension for the child? |
| 43. | How does pregnancy hypertension affect the growth of the baby? |
| 44. | What is the best way to follow up women who experience pregnancy hypertension? |
| 45. | Do pregnancy characteristics predict infant and child morbidity? |
| 46. | What is the effectiveness and safety of aspirin for prevention of pre-eclampsia? |
| 47. | What are the links between maternal emotional well-being and pregnancy hypertension? |
| 48. | What non-pharmacological treatments are effective in treating high blood pressure following pregnancy hypertension? |
| 49. | How do sleep disorders affect pregnancy hypertension? |
| 50. | What are patient-reported outcomes of interest related to hypertension in pregnancy? |
The first 25 listed above were highly ranked in the survey and therefore brought forward to the final prioritisation workshop.