FIGURE 2.

Effects of sitravatinib on IC₅₀ values of chemotherapeutic drugs in drug‐selected resistant cell lines and their parental cell lines. A. IC₅₀ values of paclitaxel, doxorubicin, vincristine, and cisplatin in ABCB1‐overexpressing KB‐C2 and KB‐3‐1 cells with or without inhibitor for 72 h. B. Cytotoxicity of ABCB1‐substrate drugs (paclitaxel, doxorubicin, vincristine) and cisplatin on SW620/Ad300 and parental SW620 cells with or without inhibitor for 72 h. Verapamil at 3 µmol/L was used as positive reversal agent. Data are shown as mean ± SD obtaining from at least 3 independent experiments. * P < 0.05 was considered statistically significant compared with control group.