Fig 2. Oxfendazole provides sterile cure in a dose-dependent manner.
L. sigmodontis adult worm burden of mice 75 dpi, subcutaneously infected with 40 infective L3 larvae and treated orally (PO) twice per day for five consecutive days (5d) starting at 35 dpi with 1, 5, or 25 mg/kg body weight of oxfendazole (n = 11 per group). Untreated controls received no oral treatments. Medians of a single experiment are shown. Kruskal-Wallis H-test: χ2 = 29.62, df = 3, p<0.0001 followed by Dunn’s multiple comparison test.