Fig 4. Comparison of the macrofilaricidal efficacy of oral and subcutaneous treatment routes for oxfendazole.
L. sigmodontis adult worm burden 78 dpi in mice naturally infected with L. sigmodontis and treated for five consecutive days (5d) with oxfendazole twice per day orally (PO) with 2.5 (n = 5) or 12.5 mg/kg body weight (n = 6) and once per day subcutaneously (SC) (n = 6 per group) with 1, 5 or 25 mg/kg oxfendazole. Untreated controls (n = 6) received no oral or subcutaneous treatments. Medians of a single experiment are shown. Kruskal-Wallis H-test: χ2 = 29.26, df = 5, p<0.0001 followed by Dunn’s multiple comparison test.