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. 2020 Jul 6;14(7):e0008427. doi: 10.1371/journal.pntd.0008427

Fig 7. Oxfendazole has no in vivo efficacy against microfilariae of L. sigmodontis.

Fig 7

Time-course of microfilariae counts in 50 μl peripheral blood of mice injected with 100,000 microfilariae and treated the following day with oxfendazole twice daily (OXF, BID) for five days with 12.5 mg/kg per os or a single intraperitoneal dose of ivermectin (IVM, 5 mg/kg). Control animals received no treatment. Means ± SEM of 6 mice per group of one single experiment are shown. Two-way ANOVA: F(2, 135) = 29.16, p<0.0001 followed by Dunnett’s multiple comparison test. p<0.0001 for IVM and p = 0.60 for oxfendazole in comparison to untreated controls.