Fig 6. A. simplex crude extract leads to oxidative stress.

Reactive oxygen species production, expressed as relative fluorescence, in Caco-2 cells after incubation for 1 and 4 hours with 2, 1 and 0.5mg/mL CE. The results are expressed as mean ± SD. The asterisks indicate significant differences between the control (0mg/mL) and 2mg/mL 1hour (P = 0.048, 95%CI = -1.8—-0.1) and 4 hours (P = 0.008, 95%CI = -2.9—-0.75), and 1mg/mL 1hour (P = 0.036, 95%CI = -1.2—-0.5).