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. Author manuscript; available in PMC: 2020 Jul 16.
Published in final edited form as: Clin Neurophysiol. 2019 Mar 28;130(6):925–940. doi: 10.1016/j.clinph.2019.03.008

Figure 5. Epigenetic mechanisms of gamma oscillations.

Figure 5.

CaMKII modulates P/Q-type channels to produce gamma oscillations (green structures). These oscillations were blocked and ICa reduced in PPN cells after inhibiting HDAC I and II (brown and blue structures) using TSA. The CaMKII blocker KN-93 was found to partially blunt the effects of TSA, suggesting that HDAC II effects on CaMKII and its modulation of P/Q-type channels are required for gene transcription. There were no effects on oscillations or ICa following inhibition of HDAC I using MS275, or of HDAC IIb using tubastatin A. On the other hand, HDAC IIa inhibition using MC1568 had the same effect as TSA in reducing oscillations and ICa. These effects were evident in cells with P/Q-type channels (N+P/Q and P/Q-only cells) but not on N-only cells that are modulated by cAMP/PKA (purple structures).