Table 2.
Comparison of morphological oocyte parameters between the letrozole group (n=750 oocytes) and the control group (n=699 oocytes)
| Parameters | Letrozole | Control | p value* |
|---|---|---|---|
| Cortical Granules | < 0.001 | ||
| No | 604 (80.5) | 292 (41.8) | |
| Yes | 146 (19.5) | 407 (58.2) | |
| Increased Perivitelline Space | 0.007 | ||
| No | 490 (65.3) | 503 (72.0) | |
| Yes | 260 (34.7) | 196 (28.0) | |
| ZP altered staining | < 0.001 | ||
| No | 743 (99.1) | 657 (94.0) | |
| Yes | 7 (0.9) | 42 (6.0) | |
| Irregular ZP | < 0.001 | ||
| No | 641 (85.5) | 668 (95.6) | |
| Yes | 109 (14.5) | 31 (4.4) | |
| Refractile Bodies | < 0.001 | ||
| No | 344 (45.9) | 385 (55.1) | |
| Yes | 406 (54.1) | 314 (44.9) | |
| Dark Ooplasm | < 0.001 | ||
| No | 522 (69.6) | 587 (84.0) | |
| Yes | 228 (30.4) | 112 (16.0) | |
| Granular Ooplasm | < 0.001 | ||
| No | 418 (55.7) | 481 (68.8) | |
| Yes | 332 (44.3) | 218 (31.2) | |
| Irregular Ooplasm | < 0.001 | ||
| No | 625 (83.3) | 685 (98.0) | |
| Yes | 125 (16.7) | 14 (2.0) | |
| Dense Central Granulation | 0.001 | ||
| No | 687 (91.6) | 670 (95.6) | |
| Yes | 63 (8.4) | 29 (4.1) | |
| Retraction | 0.254 | ||
| No | 696 (92.8) | 659 (94.3) | |
| Yes | 54 (7.2) | 40 (5.7) | |
| Vacuoles | 0.974 | ||
| No | 717 (95.6) | 668 (95.6) | |
| Yes | 33 (4.4) | 31 (4.4) | |
| Smooth ER aggregates | < 0.001 | ||
| No | 749 (99.9) | 681 (97.4) | |
| Yes | 1 (0.1) | 18 (2.6) |
Values are expressed as number (%).
ZP, Zona Pellucida;
ER, Endoplasmic Reticule.
*
Significantly different if p<0.05 (Chi-Square test)