Chart 1.

List of the studies that evaluated the use of G-CSF in women submitted to assisted fertilization, which held thin endometrium and repeated failures

First author/Year Geographic Region	Study Type	Participants number	Average age	G-CSFmethod of use Date	Endometrium thikness after G-CSF (average)	Pregnancy rates (%)
Sarvi et al., 2017 Iran	RCT	TG: 13 CG: 15	TG:31.2 CG: 31.6	TG: 300 mcg IU GC: Saline	TG: 5±1.4 mm	CG: 20 TG: 15.3 **
Eftekhar et al., 2016b Iran	RCT	TG: 44 CG: 45	TG: 32.5 CG: 31.7	300 mcg IU	CG: 8.8 TG: 9.1 **	TG: 28.8 CG: 1.3 *
Xu B et al., 2015 China	Non-randomized CT	TG: 41 CG: 65	TG: 31.4 CG: 32.0	300 mcg IU	5.7mm antes 8.4 mm após*	TG: 48 CG: 25*
Tehraninejad et al., 2015 Iran	Non-randomizedCT	15	35.13	300 mcg IU eggs collecting day	3.6mm antes 7.1mm após*	20
Eftekhar et al., 2014 Iran	Non-randomized CT	TG: 34 CG: 34	TG: 30.8 CG: 28.6	300 mcg IU 12th to 13th day	5.6  CG 5.8: TG **	CG:28.6 TG:30.8 **
Shah et al., 2014 India	Prospective cohort study	EG: 231 NEG: 117	33.5	300 mcg IU 10 days from  estrogen onset	< 8mm before 10.9mm after *	37
Gleicher et al., 2013 USA	Prospective cohort study	21	40.5	300 mcg IU on hCG day	5.7mm before 9.3mm after*	19.1
Gleicher et al., 2011 USA	Prospective cohort study	4	38.3	300mcg IU 48 h beforeET	4.9mm before 8.7mm after*	100 (1 ectopic)
Mishra et al., 2016 India	Cross-sectional study	35	30.5	300 mcg IU on 14th day of cycle	5.9mm before 6.6mm after *	Zero
Kunicki et al., 2014 Poland	Cross-sectional study	37	34.7	300 mcg IU on hCG day	6.7 before 8.4 after *	19.1

RCT: Randomized clinical trial. IU: intrauterine; ET: Embryo Transfer; CT: Clinical Trial;

SD: Standard Deviation; IR: implantation Rate;

^*Significant;

^**not significant.

TG: Treated Group.

CG: Control Group, EG: Exposed Group; NEG: Non-Exposed Group.