Table 1.

Histopathological diagnosis for each of the 12 English springer spaniels included in the study

Patient	Histopathological diagnosis
1	Hepatitis, interface, lymphocytic, plasmacytic and neutrophilic, chronic, mild, with moderate to marked hepatocyte apoptosis. Grade 1 copper
2	Hepatitis, periportal, lymphocytic and neutrophilic, chronic, marked, with moderate porto-portal bridging fibrosis. Grade 2 copper
3	Hepatitis, lymphocytic, plasmacytic and neutrophilic, chronic, moderate, with moderate hepatocyte apoptosis and necrosis. Grade 2 copper
4	Hepatitis, interface, lymphocytic, plasmacytic and neutrophilic, chronic, severe, with mild porto-portal bridging fibrosis. Grade 2 copper
5	Hepatitis, periportal, lymphocytic and neutrophilic, chronic, marked with moderate hepatocyte apoptosis and necrosis. Grade 2 copper
6	Hepatitis, periportal, lymphocytic, plasmacytic and neutrophilic, chronic, marked, with mild porto-portal bridging fibrosis. Grade 1 copper
7	Hepatitis, interface, lymphocytic, plasmacytic and neutrophilic, chronic, severe, with mild biliary hyperplasia and hepatocyte necrosis. Grade 2 copper
8	Hepatitis, lymphocytic, plasmacytic, chronic, moderate, with moderate porto-portal bridging fibrosis. Grade 1 copper
9	Hepatitis, lymphocytic, plasmacytic, chronic, moderate, with moderate portal fibrosis and portal biliary hyperplasia. Grade 1 copper
10	Hepatitis, lymphocytic, plasmacytic, subacute, moderate. Grade 2 copper
11	Hepatitis, lymphocytic, plasmacytic and neutrophilic, subacute, moderate, with occasional pigmented histiocytes and mild hepatocyte apoptosis. Grade 2 copper
12	Hepatitis, lobular and interface, lymphocytic and neutrophilic, chronic, severe with mild portal fibrosis. Grade 1 copper