Table 2.

Clinical signs documented for each of the 12 English springer spaniels reported in the study, both at enrolment and at the first recheck appointment (2–4 weeks after initiation of prednisolone therapy) with additional treatments

Patient	Clinical signs at diagnosis	Clinical signs at first recheck	Additional treatments
1	Reduce appetite, vomiting, jaundice	Resolution of jaundice and no abnormal clinical signs currently reported by owner.	UDCA, SAMe, amoxicillin-clavulanate
2	PUPD	Resolution of PUPD according to owner.	UDCA, SAMe
3	Anorexia, PUPD, vomiting, weight-loss, jaundice, lethargy	Jaundice still identified during clinical examination and appetite improved but reduced compared with normal. Resolution of vomiting, PUPD and lethargy according to owner, however weight-loss continued. The patient subsequently developed neurological abnormalities with worsening jaundice, and was euthanased 122 days after initiating prednisolone therapy.	UDCA, SAMe, metronidazole
4	Lethargy, reduced appetite, vomiting, jaundice.	Jaundice not identified during clinical examination and no abnormal signs currently reported by the owner.	UDCA, SAMe
5	No abnormal clinical signs reported by owner	Still reported to be clinically normal by owner.	UDCA, SAMe, hepatic diet
6	No abnormal clinical signs reported by owner	Still reported to be clinically normal by owner.	SAMe, hepatic diet
7	No abnormal clinical signs reported by owner	Still reported to be clinically normal by owner.	SAMe
8	Jaundice, ascites, weight-loss	Resolution of jaundice and ascites during clinical examination. No abnormal signs currently reported by the owner. The patient subsequently developed neurological abnormalities and melaena, and was euthanased 741 days after initiating prednisolone therapy.	UDCA, SAMe, spironolactone
9	Reduced appetite and PUPD	PUPD still present but improved, according to owner. Appetite now normal.	UDCA, SAMe
10	No abnormal clinical signs reported by owner	Still reported to be clinically normal by owner.
11	Vomiting, lethargy, jaundice, ascites, PUPD	Mild PUPD and polyphagia reported by owner, otherwise no abnormal clinical signs.	Hepatic diet
12	Lethargy, diarrhoea, vomiting	Resolution of vomiting and diarrhoea but owner still reported mild lethargy.	SAMe, hepatic diet, cefalexin

PUPD, polyuria/polydipsia; SAMe, S-adenosylmethionine; UDCA, ursodeoxycholic acid.