Table 1.
Exemplary mouse and rat substrains and phenotypes that can be subjected to RCC analysis.
| Mouse progenitor strains | Sequenced Mouse Substrains (on miniMUGA array) | Behavioral differences | Physiological, disease model differences | Oellular differences | Molecular differences |
|---|---|---|---|---|---|
| A | A/J, A/JOlaHsd | Muscle dysfunction [T1] | |||
| BALB/c | BALB/cJ, BALB/cByJ | Aggressio n[T2], alcohol preference[T3], anxiety-like behavior[T4], cognitive flexibility[T5], inhibitory control[T6], epilepsy and neuroanatomical abnormalities[28],[T7 ] |
Allergic orchitis and encephalomyelitis [T8,T9], immune response to infection[T10], Grave’s hyperthyroidism[T11], experimental arthritis and spondylitis[T12], GABA transmission and anterior cingulate volume[T13,T14], cardiac calcinosis[T15], dexamethasone-induced osteonecrosis[T16], diet-induced fatty liver[T17], streptozotocin-induced diabetes[T18] | Sperm abnormalities[T19], antibody-mediated immunity[T20], hepatocyte invasion following infection[T21, virus-induced demyelination[T22] | Copy number variants[T23], amino acid and monoamine neurotransmitter content in caudate[T24] |
| C3H | C3H/HeJ, C3H/HeNCrl, C3H/HeNRj, C3H/HeH, C3H/HeNHsd, C3H/HeNTac | Nest building[T25], paw preferenc e[T26] | Skeletal[T25], immune reactivity[T27], LPS responsiveness[T28], experimental leprosy[T29], spontaneous colitis[T30], experimental arthritis and spondylitis[T31], absence seizures[T32] | Cytotoxic activity of lymphocytes in cancer model[T33], | Toll-like receptor 4[T34], Gpr179[T35] |
| C57BL/6 | C57BL/6NJ, C57BL/6NCrl, C57BL/6JBom Tac, C57BL/6ByJ, C57BL/6JOlaH sd, C57BL/6NTyr<c>/BrdCrC rl, C57BL/6NJRj |
Several. Reviewed by [5]. See also [6], [T36], and main text, corticoster one-induced depressive-like behaviors[T37], | Several. Stroke[25], metabolic traits[T38], immune response[T39]. See also[6], kidney stones[T40], severity of Dravet syndrome model with Scn1a +/− [T41], circadian disruptive effects on behavior[T42], ocular lesions[T43], liver production of reactive oxygen species[T44], pain[5,24], viral-induced inflammation[T45], hindlimb unloading-induced bone loss[T46], inflammation-induced neutrophil recruitment[T47], high fat diet-induced obesity[T48], and metabolic and skeletal dysfunction[T49], impaired glucose secretion[T50], auditory physiology and pathology[T51], blood pressure[T52] | Several[6], cardiac fibrogenic response to angiotensin[T53], acetaminophen-induced hepatotoxicity[T54], hypoxic-ischemic brain injury[T55] | Gabra2[67], Cyfip2[10,11], Crb1[T56], Nlrp12[T57] |
| DBA/1 | DBA/1LacJ, DBA/1OlaHsd | Giant lysosomes in the kidney proximal tubules[T58], collagen-induced arthritis[T59] | C5[T60] | ||
| DBA/2 | Methamph etamine intake[21], acoustic startle [T61, T62] | Viral infection susceptibility[T63] | Klrd1 (CD94)[T64], Taar1[21] | ||
| FVB | FVB/NJ, FVB/NCrl, FVB/NRj, FVB/NHsd, FVB/NTac | Breast cancer[T65], pituitary abnormalities[T66], T-cell dysfunction and cutaneous pathology[T67] | |||
| NOD | NOD/ShiLtJ, NOD/MrkTac | Cataracts[T68], diabetes resistance[T69] | Structural variants in chromosome3 and Icam2 (chromosome 11)[T70] | ||
| 129 | 129Ps/OlaHsd, 129S1/SvImJ, 129S2/SvHsd, 129S2/SvPas OrlRj, 129S5/SvEvBrd, 129T2/SvEmJ, 129X1/SvJ | Opioid addiction-related behaviors[T71,T72], fear conditioning[T73,T74], anxiety-like behavior[T74,T75,T76], habituation[T74], reversal learning[T77], spatial learning/memory[T77], forced swim test[T76], m, k,.cocaine motivation [T78] | Inhibition of NaCl response in chorda tympani[T79] | Disc1 deletion[T80] | |
| Rat progenitor strains | Sequenced Rat Substrains | Behavioral differences | Physiological differences | Cellular differences | Molecular differences |
| WKY | WKY/NCrl vs WKY/NHsd | Attention[T81,T82], anxiety-like behavior[T83, social interaction [T83] | Tyrosine hydroxylase, dopamine transporter[T84], hippocampal gene expression[T85] | ||
| SHR | SHRSP vs SHRSP5/Dmcr | progression of fibrosis induced by high fat diet[T86] | |||
| SHR | SHR vs SHRSP | cerebral stroke[T87] | |||
| WKY | WLI/Eer | Open field[T88], FST[T89], stress-enhanced fear conditioning and alcohol consumption[60], response to chronic stress[59], Premature memory decline[T90] | Resting state functional connectivity[T91], baseline and stress corticosterone levels[T92] | Blood transcriptome[T92], amygdala transcriptome[T89], hippocampal transcriptome[T89, T93] | |
| WKY SS |
WMI/Eer | Open field[T88], FST[T89], stress-enhanced fear conditioning[60], alcohol consumption[60], response to chronic stress [59], premature memory decline[T90] | Baseline and stress corticosterone levels[60], blood pressure[T94] | Blood transcriptome[104], hippocampal transcriptome [T89,T93], and amygdala transcriptome[T89] | |
| SS/Jr vs SS/JrHsdMcwi vs SR/Jr | |||||
| F344 | F344/NHsd vs F344/NCrHsd | Body weight gain, neuropeptide Y and agouti-related protein[T95] | |||