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Schematic of CDK12 mutations identified in the patient cohort. Mutations were primarily truncation mutations in the RS, PRM, or kinase domains, or alternatively missense mutations in the kinase domain. Additional details regarding the CDK12 mutations are outlined in Supplementary Table 1.
CDK12 = cyclin-dependent kinase 12; RS = arginine-serine domain; PRM = proline-rich motif.
