Chapter 1 Research Papers: Titles and Abstracts

. 2020 Jul 17:1–14. doi: 10.1007/978-3-030-44214-9_1

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In this paper we investigate whether clomiphene citrate (CC) treatment affect the biosynthesis and metabolism of both sexual hormones and glucocorticoid in functional obese hypogonadal men, considering the presence of both LH and estrogen receptors on both the gonadal and adrenal glands. CC treatment in functional male hypogonadism has been shown to increase endogenous serum T and estrogen levels by stimulating Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) secretion from hypothalamus and pituitary gland. We observed that the fold changes induced by CC compared with those observed after Plac, were significantly higher for ..	In this paper we show that CC therapy can stimulate the steroidogenesis both in the testis and in the adrenal gland, as was proved by the rise in serum testosterone (T) and cortisol (F) levels in all our participants. Furthermore, .... CC treatment in functional male hypogonadism has been shown to increase endogenous serum T and estrogen levels by .... We adopted a randomized cross-over double blind controlled study (RCT) using ... A total of 21 out of the 24 enrolled obese hypogonadal men concluded the study. Inclusion criteria were: ...We observed that the fold changes induced by CC compared with those observed after Plac, were significantly higher for .... Although this study is the first to detect an effect of CC on both testicular and adrenal steroidogenesis. However, ... In conclusion, CC is able to increase T production in obese dysnetabolic hypogonadal patients and should be considered as ...

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YES!

In this paper we investigate whether clomiphene citrate (CC) treatment affect the biosynthesis and metabolism of both sexual hormones and glucocorticoid in functional obese hypogonadal men, considering the presence of both LH and estrogen receptors on both the gonadal and adrenal glands. CC treatment in functional male hypogonadism has been shown to increase endogenous serum T and estrogen levels by stimulating Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH) secretion from hypothalamus and pituitary gland. We observed that the fold changes induced by CC compared with those observed after Plac, were significantly higher for ..

In this paper we show that CC therapy can stimulate the steroidogenesis both in the testis and in the adrenal gland, as was proved by the rise in serum testosterone (T) and cortisol (F) levels in all our participants. Furthermore, .... CC treatment in functional male hypogonadism has been shown to increase endogenous serum T and estrogen levels by .... We adopted a randomized cross-over double blind controlled study (RCT) using ... A total of 21 out of the 24 enrolled obese hypogonadal men concluded the study. Inclusion criteria were: ...We observed that the fold changes induced by CC compared with those observed after Plac, were significantly higher for .... Although this study is the first to detect an effect of CC on both testicular and adrenal steroidogenesis. However, ... In conclusion, CC is able to increase T production in obese dysnetabolic hypogonadal patients and should be considered as ...