Table 2.
Presurgical clinical and biochemical features of patients with adrenal incidentalomas and with cortisol after 1 mg overnight dexamethasone suppression test <1.2 µg/dL or ≥1.2 µg/dL
| F-1mgDST <1.2 µg/dLn = 9 | F-1mgDST ≥1.2 µg/dLn = 51 | P value | |
|---|---|---|---|
| Females | 6 (66.7) | 40 (78.4) | .44 |
| Age (years) | 56.6 ± 4.5 48-63 | 55.9 ± 11.6 24-75 | .86 |
| BMI (kg/m2) | 26.6 ± 2.9 21.5-31.3 | 28.4 ± 6.0 17.4-41.0 | .38 |
| Duration of presurgical follow-up (months) | 8.4 ± 7.4 1.0 − 24.0 | 5.5 ± 5.0 0.5 − 19.6 | .142 |
| HC doses (mg/day) | 20.0 ± 0.0 [20] | 21.1 ± 2.5 [20, 30] | .21 |
| ACTH (pg/mL) | 10.1 ± 6.0 5.0-23.8 | 9.3 ± 5.2 1.9-26.9 | .69 |
| F-1mg-DST (µg/dL) | 1.1 ± 0.1 0.9-1.1 | 4.6 ± 3.2 1.2-13.7 | .001 |
| UFC (µg/24 hours) | 36.6 ± 17.7 10.0-59.0 | 66.8 ± 43.2 10.4-189.6 | .04 |
| MSC (µg/dL) | 3.0 ± 1.6 1.0-5.5 | 5.4 ± 3.1 1.2-12.5 | .03 |
| Diameter of adenoma (cm) | 3.4 ± 1.2 1.5-5.7 | 3.5 ± 1.3 1.2-9.0 | .85 |
| Pts with type 2 diabetes mellitus (%) | 0 (0.0) | 14 (27.5) | .07 |
| Pts with arterial hypertension (%) | 3 (33.3) | 30 (58.8) | .15 |
| Pts with obesity (%) | 3 (33.3) | 22 (43.1) | .72 |
| Pts with dyslipidemia (%) | 0 (0.0) | 22 (43.1) | .02 |
| Pts with metabolic syndrome (%) | 0 (0.0) | 11 (21.6) | .19 |
For plasma cortisol multiply × 27.56 to convert from µg/dL to nmol/L. For 24 hour urinary cortisol multiply × 2.756 to convert from µg/24 hours to nmol/24 hours. For ACTH multiply × 0.22 to convert from pg/mL to pmol/L.
Abbreviations: ACTH, adrenocorticotropin; Pts, patients; MSC, midnight serum cortisol; UFC, urinary free cortisol; F-1mgDST, cortisol after 1 mg overnight dexamethasone suppression test. HC, hydrocortisone dose during substitutive therapy period.