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. Author manuscript; available in PMC: 2021 Mar 26.
Published in final edited form as: J Med Chem. 2020 Mar 10;63(6):2854–2876. doi: 10.1021/acs.jmedchem.9b01189

Figure 3.

Figure 3.

(A) Effects on retinal permeability and (B) liver phenotype for compound A91 in comparison to FenoFA. 7–8 week-old male Brown Norway rats were injected with streptozotocin (STZ, 55 mg/kg) to induce diabetes. Two weeks after STZ injections, daily treatment (i.p. injection) with compound A91 or FenoFA commenced and lasted for 28 days. Student’s t-test was used to compare groups for statistical significance and values are mean ± SD, # P<0.05 (vs. FenoFA), Retinal permeability was measured using Evans blue as tracer and normalized by total retinal protein. *P<0.05 (vs. STZ-DMSO).