Table 2.

In vitro Activity of 5a, 5b, 5b^*, 5f^a

Compound	R	Ratio (5/50)b	Fold-Signalc
5a	OMe	0.1	1.8
5b	F	0.2	2.0
5b*	F	0.6	1.8
5f	CF3	0.2	1.2

^aAll analogues contain the carboxylate head-group at the meta-position of the A-ring unless otherwise indicated.

^*indicates a para-carboxylate.

^bRatio of relative light unit (RLU) signal at 5 μM and 50 μM compound concentrations.

^cRatio of maximal signal strength observed for the compound of interest to that obtained with GW590735.