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. Author manuscript; available in PMC: 2021 Mar 26.
Published in final edited form as: J Med Chem. 2020 Mar 10;63(6):2854–2876. doi: 10.1021/acs.jmedchem.9b01189

Table 3.

In vitro Activity of 4m-o

graphic file with name nihms-1577324-t0019.jpg
Compound m n R Ratio (5/50)a Fold-Signalb
4m 1 2 H 0.1 0.9
4n 1 2 OMe 0.1 0.9
4o 2 2 OMe 1.1 0.1
a

Ratio of relative light unit (RLU) signal at 5 μM and 50 μM compound concentrations.

b

Ratio of maximal signal (RLU) strength observed for the compound of interest to that obtained with GW590735.