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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Hepatology. 2020 Jun 29;72(4):1191–1203. doi: 10.1002/hep.31115

Figure 7. The anti-NAFLD effects of indole was impaired in myeloid cell-specific PFKFB3 deficient mice.

Figure 7.

Male Mye-PFKFB3–/– and Mye-PFKFB3+/+ mice, at 5 – 6 weeks of age, were fed an HFD for 12 weeks and treated with indole (orally, 50 mg/kg) or control (Ctrl) daily for the last 4 weeks of HFD feeding. (A) Plasma levels of ALT. (B) Liver weight. (C,D) Liver sections were stained with H&E (C) or for F4/80 (D). (E) Liver lysates were examined for proinflammatory signaling. Bar graphs, quantification of blots. (F) Liver gene was analyzed usig real-time PCR. For A, B, E, and F, numeric data are means ± SEM, n = 10 – 12 (A and B) and 6 – 8 (E and F). *, P < 0.05 and **, P < 0.01 Mye-PFKFB3–/– vs. Mye-PFKFB3+/+ under the same condition (Ctrl or Indole in A, B, and E); †, P < 0.05 and ††, P < 0.01 Indole vs. Ctrl within the same genotype (Mye-PFKFB3+/+ in E).