TABLE 1.
Patient Characteristics in Propensity-Matched RISK-PROKIIDS Comparator Groups
| Characteristic | Standard Care | Early Intervention With Biologics | P |
|---|---|---|---|
| n = 237, No. (%) | n = 123, No. (%) | ||
| Sex, female | 75 (31.6) | 41 (33.3) | 0.837 |
| Age at diagnosis, mean (SD), y | 12.27 (2.65) | 12.28 (2.70) | 0.964 |
| Albumin, mean (SD), g/dL | 3.46 (0.59) | 3.43 (0.62) | 0.717 |
| Height Z score, mean (SD) | –0.38 (1.08) | –0.45 (1.21) | 0.577 |
| Family history of IBD | 0.164 | ||
| No 1st-degree relative | 185 (78.1) | 107 (87.0) | |
| One 1st-degree relative | 41 (17.3) | 14 (11.4) | |
| Two 1st-degree relatives | 3 (1.3) | 0 (0.0) | |
| Unknown | 8 (3.4) | 2 (1.6) | |
| Ethnicity | 0.335 | ||
| Caucasian | 176 (74.3) | 88 (71.5) | |
| African | 21 (8.9) | 12 (9.8) | |
| Mixed | 18 (7.6) | 7 (5.7) | |
| Other | 10 (4.2) | 9 (7.3) | |
| Unknown | 12 (5.1) | 7 (5.7) | |
| Presence of perianal disease | 0.048* | ||
| No | 169 (71.3) | 72 (58.5) | |
| Yes | 66 (27.8) | 50 (40.7) | |
| Unknown | 2 (0.8) | 1 (0.8) | |
| Disease activity at diagnosis (Physician Global Assessment) | 0.235 | ||
| None | 3 (1.3) | 0 (0.0) | |
| Mild | 59 (24.9) | 23 (18.7) | |
| Moderate | 121 (51.1) | 74 (60.2) | |
| Severe | 54 (22.8) | 26 (21.1) | |
| Disease location | 0.962 | ||
| No L1–L3 disease | 0 (0.4) | 1 (0.8) | |
| L1 | 33 (13.9) | 17 (13.8) | |
| L2 | 48 (20.3) | 23 (18.7) | |
| L3 | 136 (57.4) | 70 (56.9) | |
| Unknown | 19 (8.0) | 12 (9.8) |
Chi-square test, t test, and Kruskal-Wallis rank-sum tests were used for comparisons between groups depending on continuous or noncontinuous variables.
*P < 0.05.