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. 2020 Mar 14;26(8):1199–1211. doi: 10.1093/ibd/izaa049

Figure 7.

Figure 7.

The P40 and P75 of the LAB strains increase VDR and protect the organoids from inflammatory response induced by TNF-α. A, P40 and P75 proteins can be detected in the LAB strains. B, LAB increased the expression of APRIL. Data are expressed as mean ± SD; n = 3, 1-way ANOVA test, *P < 0.05, **P < 0.01 compared with 0h group. C, The expression of VDR in organoids were upregulated after P40 or P75 treatment (100ng/mL for 24 hours). Data are expressed as mean ± SD; n = 3, 1-way ANOVA test, *P < 0.05 compared with control group. D, Organoid from ileum tissue WAS treated with P40 or P75 (100 ng/mL) for 24 hours, Then added with TNF-α 0.5 ng/mL for 30 minutes. Proteins P40 and P75 upregulated the expression of VDR. The expression of IκBα was decreased after TNF-α treatment but not in the groups with P40 or P75 treatment. Data are expressed as mean ± SD; n = 3, 1-way ANOVA test, *P < 0.05, **P < 0.01 compared with control group. E, A working model of probiotic upregulation of VDR through P40 and P75 to stimulate autophagic responses and inhibit inflammation.