Table 2.
Effect of treatment on BP, SA, renin, and aldosterone
| Variable | CPAP therapeutic |
CPAP subtherapeutic |
P value | ||
|---|---|---|---|---|---|
| Pre | Post | Pre | Post | ||
| MSNA bursts/min | 47.5 (39-52.3) | 49 (35.4-52.4) | 40.4 (37.6-52.4) | 46 (38.5-53.5) | 0.99 |
| MSNA bursts/100 beats | 82 (70.9-95.3) | 90.3 (69-90.4) | 81.4 (72.4-89) | 86 (76.9-96.5) | 0.99 |
| ABPM SBP awake (mm Hg) | 144 (136-153) | 136 (133.3-144.3) | 138.5 (127.8-146.8) | 154 (152-160) | 0.045 |
| ABPM DBP awake (mm Hg) | 79 (70-88) | 73.5 (71-77.8) | 73 (67.8-80.3) | 83 (72-97) | 0.015 |
| ABPM SBP sleep (mm Hg) | 135 (124-145) | 119 (115.8-134) | 132 (124-138.8) | 146 (137-167) | 0.004 |
| ABPM DBP sleep (mm Hg) | 75 (65-83) | 65 (56.5-73.8) | 68 (63.3-76) | 81 (65-87) | 0.004 |
| ABPM SBP Overall (mm Hg) | 141 (135-150) | 133 (130.3-138.8) | 136.5 (128.8-145) | 153 (148-161) | 0.022 |
| ABPM DBP Overall (mm Hg) | 80 (69-86) | 72.5 (66.5-76.3) | 72 (65.8-79) | 84 (72-94) | 0.012 |
| Heart rate awake (beats/min) | 70 (59-79) | 67 (58-85) | 65 (61-70) | 64.5 (57-77) | 0.83 |
| Heart rate sleep (beats/min) | 66 (45-87) | 62 (50-78) | 58.5 (51-64) | 59.5 (53-70) | 0.62 |
| Heart rate overall (beats/min) | 69 (59-79) | 65 (56-85) | 65 (59-68) | 63 (56-77) | 0.61 |
| Aldosterone (pmol/L) | 178.5 (92.8-260.5) | 118.5 (76.3-152.5) | 98 (82.5-147.3) | 103 (89.8-165.8) | 0.23 |
| Plasma renin activity (ng/mL/h) | 0.55 (0.4-3.33) | 1.05 (0.8-2.2) | 1.25 (0.73-3.8) | 0.4 (0.2-3.7) | 0.85 |
| Norepinephrine (pg/mL) | 341 (266.5-669) | 428 (368.5-794.3) | 432 (368.8-478.8) | 315 (161.5-554) | 0.27 |
| Epinephrine (pg/mL) | 32 (16-33.5) | 30.5 (13-60.8) | 49.5 (10.8-158) | 20 (15-53) | 0.54 |
| BMI (kg/m2) | 30.9 (28.7-34.9) | 30.8 (28.6-34.2) | 34.2 (32.5-35.7) | 34.9 (32.2-36.6) | 0.83 |
All data presented as median (interquartile range). P relates to the effect of treatment (therapeutic vs subtherapeutic CPAP).
ABPM, ambulatory blood pressure monitoring; BMI, body mass index; BP, blood pressure; CPAP, continuous positive airway pressure; DBP, diastolic blood pressure; MSNA, muscle sympathetic nerve activity; SA, sympathetic activity; SBP, systolic blood pressure.