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. 2020 Jul 10;11:1426. doi: 10.3389/fimmu.2020.01426

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Copyright © 2020 Italiani, Mosca, Della Camera, Melillo, Migliorini, Milanesi and Boraschi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene expression profiles of IL-1 family cytokines and receptors. Expression levels of the genes of IL-1 family during the resolving and persistent inflammatory reactions. The mean expression values from three different donors for each model are reported.

logCPM: log count per million. Bars indicate standard deviation across biological replicates.

Statistically significant differences are as follows (R = resolving; P = persistent):

IL1A R24 vs. P24 P < 0.001; R48 vs. P96 P < 0.0001

IL1B R48 vs. P96 P < 0.0001

IL18 R48 vs. P96 P < 0.0001

IL36B R24 vs. P24 P < 0.05

IL36G R24 vs. P24 P < 0.0001; R48 vs. P96 P < 0.0001

IL36RN R24 vs. P24 P < 0.0001; R48 vs. P96 P < 0.001

IL1RAP R48 vs. P96 P < 0.05

SIGIRR R24 vs. P24 P < 0.05; R48 vs. P96 P < 0.05

IL18BP R24 vs. P24 P < 0.0001; R48 vs. P96 P < 0.0001

All other differences have a P > 0.05.