Figure 7.

Production of IL-1 family cytokines and receptors during resolving and persistent in vitro inflammatory reactions. Production of IL-1 family cytokines and soluble receptors during the resolving (green circles, continuous line) and persistent (red triangles, dashed line) in vitro inflammatory reactions. Production of soluble proteins released in the supernatant is reported in terms of rate of production, i.e., the amount of protein produced per million cells per hour. The individual values of three different donors are reported, with a small black dot representing the mean value. Statistical significance was calculated with one-way ANOVA followed by Tukey's multiple comparisons test for significant differences between two consecutive experimental time points within a model and between the two models. A P-value < 0.05 was considered statistically significant. The full statistical evaluation is reported in the Supplementary Tables 7, 8.