Table 2.
Results of linear mixed-effect models for association of metabolic syndrome with platelet aggregation and stratified by sex.
| Males | Females | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Phenotype | Beta | SE | P | N | Beta | SE | P | N | Beta | SE | P | N |
| 1 μM ADP | 0.05 | 0.78 | 9.46E-01 | 2,999 | 1.04 | 0.93 | 2.63E-01 | 1,353 | −1.14 | 1.22 | 3.52E-01 | 1,646 |
| 5 μM ADP | −3.07 | 0.71 | 1.70E-05 | 2,069 | −2.66 | 1.05 | 1.16E-02 | 1,051 | −3.77 | 0.95 | 6.78E-05 | 1,018 |
| 0.1 μM EPI | −2.92 | 1.37 | 3.26E-02 | 1,560 | 0.03 | 1.89 | 9.87E-01 | 609 | −5.18 | 1.90 | 6.38E-03 | 951 |
| 1 μM EPI | −3.11 | 1.23 | 1.15E-02 | 2,485 | −1.66 | 1.84 | 3.67E-01 | 1,134 | −4.78 | 1.65 | 3.67E-03 | 1,351 |
| COLLAGEN | 2.07 | 0.85 | 1.54E-02 | 3,144 | 1.07 | 1.25 | 3.96E-01 | 1,473 | 3.47 | 1.16 | 2.82E-03 | 1,671 |
Sample size (N) at different concentrations vary due to concentration titrating scheme originally applied in FHS LTA data acquisition. ADP and EPI values are % Maximal Aggregation whereas COLLAGEN is Lag time. Main model adjusts for age, sex, aspirin usage. Sex stratified model adjusts for age, aspirin usage. SE, standard error; P, P-value.