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. 2020 Jul 10;8:616. doi: 10.3389/fcell.2020.00616

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Copyright © 2020 Kabir, Uddin, Hossain, Abdulhakim, Alam, Ashraf, Bungau, Bin-Jumah, Abdel-Daim and Aleya.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Replication cycle of SARS-CoV-2 and potential anti-SARS-CoV-2 drug targets. Following bindings of SARS-CoV-2 particles with the cell receptors including dipeptidyl peptidase 4 (DPP4), aminopeptidase N (APN), and angiotensin-converting enzyme 2 (ACE2), RNA of the virus then enters into the host cell and viral RNA transcription takes place via RNA-dependent RNA polymerase (RdRp). After that viral protein synthesis takes place that is encapsulated and then released from the host cell. Dotted arrows have been used to indicate the drug targets of investigational therapies for nCOVID-19.