Table 2.

Overview of drugs that regulate microglia activation and polarization.

Drug	Animal model	Time window	Depletion efficiency	Repopulation	References
CSF1R inhibitor (PLX3397)	/	7 or 21 days	90% or 99%	Yes	Elmore et al. (2014)
CSF1R inhibitor (PLX3397)	Cerebral ischemia	21 days	97%	Not shown	Szalay et al. (2016)
CSF1R inhibitor (PLX3397)	/	7 days	99%	Yes	Najafi et al. (2018)
CSF1R inhibitor (PLX5562)	Radiation injury	3 days	95%	Not shown	Acharya et al. (2016)
CSF1R inhibitor (GW2580)	Spinal cord injury	10 weeks	not shown	Not shown	Gerber et al. (2018)
Liposomal clodronate	/	1 or 5 days	80%	Yes	Torres et al. (2016)
Mac-1-saporin	Spinal microglia depletion	1 day	50%	Yes	Yao et al. (2016)