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. 2020 Jul 10;8:540. doi: 10.3389/fcell.2020.00540

FIGURE 2.

FIGURE 2

MiR-138 treatment decreases the mRNA and protein expression levels of CCND3, CDC20, MCM2, and Ki67 in A549 tumors and A549 cells. (A) Lent-miR-138 treatment (lent-M) decreased the gene expression levels of CCND3, CDC20, MCM2, and Ki67 in tumors from A549 bearing mice, compared with the Lent-NC treated (lent-N) and non-treated tumors. (B) Decreased gene expression levels of CCND3, CDC20, MCM2, and Ki67 in lent-miR-138-5p treated A549 cells, lent-NC treated cells and untreated cells. (C) Lent-miR-138- treatment decreased the protein expression levels of CCND3, CDC20, MCM2, and Ki67 in A549 tumors or (D) A549 cells. (Three independent assays were performed; **P < 0.01, ***P < 0.001).