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. 2020 Jul 10;8:540. doi: 10.3389/fcell.2020.00540

FIGURE 3.

FIGURE 3

MiR-138-5p treatment changed the statues of DCs in tumor. (A) The percentage of mature DCs (DCm), regulatory DCs (DCreg) and the ratios of regulator DCs to mature DCs (DCreg/DCm) in tumors from A549 bearing mice, which were treated with lent-miR-138 (Tumor + lent-M) or lent-NC (Tumor + lent-N) or not (Tumor). (B) The expression levels of CD80, CD86 and I-Ab on tumor infiltrating DCs from lent-M, lent-N treated A549 bearing mice or not. (C) The inhibit ration of tumor infiltrating DCs from lent-M, lent-N treated A549 bearing mice or not (mock). Tumor infiltrating DCs were isolated from every group and incubated with A549 cells for 24 h, and the apoptosis ratio of A549 cells was analyzed by flow cytometry. (D) With lent-M/lent-N treatment or not, the expression of CD80, CD86, and I-ab on isolated DCs cells. There are no significantly different between every group. (E) With lent-M, lent-N treatment, the inhibit ration of DCs on A549 cells were analyzed. There are no significantly different between every group. (**P < 0.01, ***P < 0.001).