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. 2020 Jul 10;8:784. doi: 10.3389/fbioe.2020.00784

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Copyright © 2020 Elsayed, Faroni, Ashraf, Osuji, Wunderley, Zhang, Elsobky, Mansour, Zidan and Reid.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemistry of in vitro model of degeneration showing degenerative changes to both myelin lipids, myelin proteins and axons. Panel (A) showed MBP/βIIIT/P0 staining with evident degeneration at D14 and Fluoro-Myelin staining with lipid degeneration. (D0) Compact homogenous organised myelin and axons resembling normal nerve. (D3) Loosening and disorganisation of myelin with multiple discontinuity. (D7) Continued loosening and disorganisation with greater disruption of myelin structure. (D14) Consolidated mass with loss of architecture. CD68 staining with gradual increase in numbers of cells after degeneration induction. (B,C) Gradual increase of % area of DAPI staining in desheathed explants at different time points showing significant increase at D14. (D0 is control.) (**P < 0.001) Scale bar for MBP, P0, βIIIT, Fluoro-Myelin and DAPI is 40 μm. Scale bar for CD68 is 200 μm.