Table 1.

Effect of HFHFD Feeding on Plasma Biochemistry

Biochemical plasma analysis	CD	HFHFD	P
AST, U/L
10–15 wk	172 (124–225)	127 (106–166)	.423
20–25 wk	107 (88–147)	244 (199–326)	<.001
32 wk	110 (76-188)	318 (266-457)	<.001
ALT, U/L
10–15 wk	7 (6–13)	6 (6–12)	.568
20–25 wk	6 (6–6)	19 (6–40)	<.001
32 wk	15 (13–30)	141 (121–191)	<.001
Fasted glycemia, mg/dL
10–15 wk	128 (119–149)	188 (159–213)	<.001
20–25 wk	149 (130–173)	236 (220–255)	<.001
32 wk	155 (135–172)	197 (179–225)	.002
Total cholesterol, mg/dL
10–15 wk	58 (57–62)	125 (119–129)	<.001
20–25 wk	63 (55–64)	140 (132–152)	.002
32 wk	63 (61–70)	178 (169–192)	<.001
LDL, mg/dL
10–15 wk	7 (4–9)	16 (13–17)	.051
20–25 wk	7 (6–8)	24 (19–30)	<.001
32 wk	6 (5–8)	26 (22–30)	<.001
HDL, mg/dL
10–15 wk	48 (38–53)	97 (84–106)	.014
20–25 wk	41 (39–49)	87 (64–133)	.035
32 wk	59 (55–64)	138 (116–154)	<.001
Triglycerides, mg/dL
10–15 wk	115 (91–141)	71 (56–91)	.073
20–25 wk	93 (74–129)	54 (48–74)	.035
32 wk	107 (94–120)	67 (64–76)	.016
Leptin, ng/mL
10–15 wk	2 (2–2)	77 (68–80)	.008
20–25 wk	7 (6–14)	70 (64–74)	.016
32 wk	20 (12–48)	78 (77–79)	.004
Adiponectin, μg/mL
10–15 wk	41 (38–43)	70 (61–74)	.004
20–25 wk	45 (43–51)	60 (59–61)	.030
32 wk	64 (49–65)	58 (55–59)	.931

NOTE. Data are presented as the median (interquartile range). Statistical analysis was performed with the Mann–Whitney U test. Significant P values are in bold.

AST, aspartate aminotransferase; HDL, high-density lipoprotein cholesterol; LDL low-density lipoprotein cholesterol.