Table 4.
Effect of Diet Reversal on Plasma Biochemistry
| Biochemical plasma analysis | CD 32 wk (1) | Diet reversal (2) | HFHFD, 20 wk (3) | HFHFD, 32 wk (4) | P | P, (1) vs (2) | P, (2) vs (3) | P (2) vs (4) |
|---|---|---|---|---|---|---|---|---|
| AST, U/L | 110 (76–188) | 182 (113–259) | 245 (212–322) | 318 (266–457) | .002 | .165 | .228 | .013 |
| ALT, U/L | 15 (13–30) | 10 (6–14) | 19 (6–45) | 141 (121–191) | <.001 | .278 | .387 | <.001 |
| Fasted glycemia, mg/dL | 155 (135–172) | 178 (156–185) | 236 (220–257) | 197 (179–225) | <.001 | .159 | <.001 | .032 |
| Total cholesterol, mg/dL | 63 (61–70) | 64 (60–72) | 140 (133–157) | 178 (169–192) | <.001 | .853 | .004 | <.001 |
| LDL, mg/dL | 6 (5–8) | 8 (7–9) | 21 (17–32) | 26 (22–30) | <.001 | .123 | <.001 | <.001 |
| HDL, mg/dL | 59 (55–64) | 65 (51–80) | 112 (81–137) | 138 (116–154) | <.001 | .436 | .122 | .001 |
| Triglycerides, mg/dL | 107 (94–120) | 135 (98–149) | 61 (51–72) | 67 (64–76) | <.001 | .247 | <.001 | <.001 |
| Leptin, ng/mL | 20 (12–48) | 44 (18–69) | 70 (69–72) | 78 (77–79) | .019 | .247 | .643 | .093 |
| Adiponectin, μg/mL | 64 (49–65) | 56 (51–60) | 61 (60–61) | 58 (55–59) | .717 |
NOTE. Data are presented as medians (interquartile range). Statistical analysis was performed with the Kruskal–Wallis test according to a stepwise step-down method to determine homogenous subsets. Significant P values are in bold.
AST, aspartate aminotransferase.