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. 2020 Jul 7;26(25):3577–3585. doi: 10.3748/wjg.v26.i25.3577

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Catabolic pathways regulating triglycerides levels in adipocytes. Adipose triglyceride lipase, hormone sensitive lipase, and monoacylglycerol lipase act on triglycerides in a series of subsequent reactions in order to generate glycerol and fatty acids. Comparative gene identification-58 binds to perilipin facilitating lipolysis, as a known activator of adipose triglyceride lipase. Intermediates of this catabolic pathway may also be re-esterified to phospholipids and triglycerides by the enzymes monoacyglycerol acyltransferases and diacylglycerol acyltransferase. ATGL: Adipose triglyceride lipase; HSL: Hormone sensitive lipase; MGL: Monoacylglycerol lipase; TGs: Triglycerides; FAs: Fatty acids; CGI-58: Comparative gene identification-58; MGAT: Monoacyglycerol acyltransferases; DGAT: Diacylglycerol acyltransferase.