A 62-year-old COVID-19-positive man presented with right-sided hemiparesis. A-C, Cerebral computed tomography showed (A) a left dense media sign, (B) occlusion on computed tomography angiography (CTA), and (C) corresponding perfusion defect. D, Digital subtraction angiography confirmed an M1 occlusion. E, After intra-arterial thrombectomy, cerebral blood flow was restored (Thrombolysis in Cerebral Infarction grade 2C).