Table 1.

Characteristics of the included studies.

Notes. N/A – non-applicable, M – male, F – female, GCS – Glasgow Coma Score, CT – Computed Tomography, MRI – Magnetic Resonance Imaging, CNS –Cerebrospinal Fluid, CSF – Chemical-physical cerebrospinal fluid, PCR– Polymerase chain reaction, RNA- Ribonucleic acid, RT-PCR – Real-time polymerase chain reaction.

* Authors provided neuroimaging results for 11/27 cases. The inclusion of those 11 cases was based onnoted abnormalities interms of white matter T2 hyperintensities (more than expected for age-related microangiopathy based on visual qualitative assessment) and/or microhemorrhages (defined as ≤ 4 mm in size). Microhemorrhages confined to any areas of acute/subacute infarcts were excluded.

** 242 out of 3661 patients were MRI scanned. The authors reportthe most common clinical indications for brain imaging in their cohort to be: altered mental status (n = 102), syncope/fall (n = 79), or focal neurologic deficit (n = 30).