. 2020 Jul 10;11:574. doi: 10.3389/fneur.2020.00574

Table 3.

Summary of neuroimaging comparisons between FTLD-non-AD and FTLD-AD groups (mean ± standard deviation).

	FTLD-non-AD	FTLD-AD	Unadjusted p	Adjusted p
N	17	7
Volumetric Analysis (Volume-to-ICV ratio × 10⁻³)
Posterior cingulate	3.60 ± 0.48^a	3.70 ± 0.60	0.42	N.S.
Inferior parietal	16.10 ± 1.80^a	13.10 ± 1.81	0.004	0.018
Precuneus	12.00 ± 1.04^a	9.70 ± 1.44	0.003	0.018
Lateral orbitofrontal	9.20 ± 1.46^a	10.00 ± 0.83	0.23	N.S.
Caudal middle frontal	6.40 ± 1.47^a	6.20 ± 0.56	0.84	N.S.
Hippocampus	5.20 ± 0.44^a	4.60 ± 0.36	0.009	0.020
Caudate	4.58 ± 0.62^a	4.45 ± 0.65	0.74	N.S.
Thalamus	7.68 ± 0.77^a	7.81 ± 0.48	0.35	N.S.
Midbrain	3.50 ± 0.44^a	4.00 ± 0.27	0.009	0.020
DTI (mm²/s)
Right SLF
FA	0.35 ± 0.03^b	0.34 ± 0.03	0.50	N.S.
MD (× 10⁻³)	0.88 ± 0.04^b	0.90 ± 0.05	0.46	N.S.
AxD (× 10⁻³)	1.21 ± 0.04^b	1.23 ± 0.04	0.17	N.S.
RD (× 10⁻³)	0.72 ± 0.05^b	0.74 ± 0.06	0.39	N.S.
Left SLF
FA	0.34 ± 0.03^b	0.34 ± 0.02	0.71	N.S.
MD (× 10⁻³)	0.89 ± 0.07^b	0.92 ± 0.04	0.13	N.S.
AxD (× 10⁻³)	1.22 ± 0.06^b	1.25 ± 0.05	0.12	N.S.
RD (× 10⁻³)	0.73 ± 0.08^b	0.75 ± 0.04	0.23	N.S.
Fornix
FA	0.20 ± 0.03^b	0.20 ± 0.02	0.71	N.S.
MD (× 10⁻³)	2.16 ± 0.22^b	2.15 ± 0.22	0.82	N.S.
AxD (× 10⁻³)	2.60 ± 0.23^b	2.58 ± 0.26	1.00	N.S.
RD (× 10⁻³)	1.94 ± 0.22^b	1.93 ± 0.20	0.82	N.S.
PET (SUVR)
Dorsal caudate	1.52 ± 0.38	1.90 ± 0.43	0.06	N.S.
Thalamus	1.43 ± 0.24	1.64 ± 0.37	0.17	N.S.
Midbrain	1.45 ± 0.30	1.42 ± 0.26	0.87	N.S.
Lateral temporal	1.33 ± 0.43	3.12 ± 1.35	0.001	0.005
Dorsolateral prefrontal cortex	1.62 ± 0.57	3.22 ± 1.76	0.005	0.009
Ventrolateral prefrontal cortex	1.53 ± 0.46	2.77 ± 1.45	0.017	0.026
Orbitofrontal cortex	1.52 ± 0.39	2.53 ± 1.23	0.004	0.009
Hippocampus	1.20 ± 0.28	1.80 ± 0.39	0.002	0.006
Inferior parietal	1.49 ± 0.56	3.26 ± 1.53	0.001	0.005

Mann–Whitney U comparisons; unadjusted significance level set at p < 0.05 (two-sided).

FDR Benjamini–Hochberg adjusted p-values presented in bold italics; significant at p < 0.05.

N.S., not significant after multiple comparisons.

DTI, diffuse tensor imaging; SLF, superior longitudinal fasciculus; PET, positron emission tomography; SUVR, standard uptake volume ratio; FA, fractional anisotropy; MD, mean diffusivity; AxD, axial diffusivity; RD, radial diffusivity.

Data for one participant are missing because of FreeSurfer preprocessing failure.

Data for three participants are missing because of movement during DTI acquisition.