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Characteristics of Acute-Onset AIH
| Approximately 25%–46% of AIH |
| A continuous spectrum from “genuine” acute hepatitis to acute exacerbation of chronic hepatitis |
| Frequently ANA seronegative and/or normal IgG |
| Liver histology is crucial for diagnosis; centrilobular necrosis, lobular and perivenular necroinflammatory activity |
| Corticosteroids as effective as in classic AIH |
AIH, autoimmune hepatitis; ANA, anti-nuclear antibodies; IgG, immunoglobulin G.
