Table 2.
Mean Values of Each Patient-Reported Outcome Measure
| PROs | Category | No. | Overall (n=355) | Disease severity | p-value | |
|---|---|---|---|---|---|---|
| Moderate (n=330)* | Severe (n=25)† | |||||
| HADS | Depression | 349 | 6.6±4.5 | 6.5±4.4 | 8.9±5.2 | 0.610 |
| Anxiety | 348 | 6.2±4.4 | 6.2±4.4 | 6.6±4.5 | 0.638 | |
| WPAI:UC | Absenteeism‡ | 149 | 29.1±36.9 | 27.3±35.8 | 54.1±43.5 | 0.102 |
| Presenteeism§ | 143 | 37.8±31.4 | 36.8±30.3 | 62.2±39.6 | 0.037 | |
| Overall work impairmentII | 130 | 45.5±32.7 | 44.1±31.9 | 70.7±37.8 | 0.048 | |
| Social activity impairment¶ | 344 | 46.4±31.2 | 45.2±31.0 | 61.2±31.0 | 0.014 | |
| IBDQ | Bowel system | 344 | 41.7±13.0 | 42.0±13.1 | 36.1±10.9 | 0.027 |
| Emotional health | 347 | 51.7±14.9 | 52.0±14.9 | 46.8±13.6 | 0.097 | |
| Systemic symptoms | 347 | 20.5±6.8 | 20.7±6.8 | 17.0±6.0 | 0.009 | |
| Social function | 309 | 23.2±7.7 | 22.8±7.9 | 18.0±6.8 | 0.003 | |
| Total score | 305 | 137.3±38.8 | 137.5±39.0 | 117.9±33.2 | 0.002 | |
Data are presented as the mean±SD.
PRO, patient-reported outcome; HADS, Hospital Anxiety and Depression Scale; WPAI, Work Productivity and Activity Impairment; UC, ulcerative colitis; IBDQ, Inflammatory Bowel Disease Questionnaire.
*
Total Mayo score 6–10 points; †Total Mayo score ≥11; ‡Absenteeism: percentage of work time missed=(Q2/[Q2+Q4])×100; §Presenteeism: percentage of impairment while working=(Q5/10)×100; IIPercentage of overall work impairment=(Q2/(Q2+Q4)+[(1–(Q2/(Q2+Q4)))×(Q5/10)])×100; ¶Percentage of social activity impairment=(Q6/10)×100; Q, questionnaire item.