Table III.

Univariate and multivariate analysis with respect to progression-free survival in 40 stage IV breast cancer patients.

	Univariate analysis			Multivariate analysis
Parameters	Hazard ratio	95% CI	P-value	Hazard ratio	95% CI	P-value
Age, years
≤64	1.138	0.516-2.511	0.749
>64
Menopausal status
Premenopausal	2.209	0.515-9.478	0.286
Postmenopausal
Degree of progression
Bone or soft tissue	0.605	0.271-1.355	0.222
Visceral metastases
TILs
High	0.527	0.208-1.339	0.178
Low
Ki67, %
≤14	1.049	0.391-2.815	0.925	1.578	0.540-4.610	0.405
>14
Response rate
ORR	0.179	0.072-0.443	<0.001	0.048	0.011-0.199	<0.001
Non-ORR
LPBC
Yes	0.158	0.037-0.680	0.013	0.058	0.010-0.333	0.001
No

CI, confidence interval; TILs, tumor-infiltrating lymphocytes; ORR, objective response rate; LPBC, lymphocyte-predominant breast cancer.