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. 2019 Aug 20;36(17):2590–2607. doi: 10.1089/neu.2018.6314

FIG. 8.

FIG. 8.

Effect of repeated unpredictable stress (RUS) on hippocampal neurotrophic factors and receptors at 3 months after the second RUS. Hippocampal brain-derived neurotrophic factor (BDNF) levels were quantified using enzyme-linked immunosorbent assay (A). Representative Western blot images for TrkB, proBDNF, and P75NTR in the hippocampus (B). Quantification of hippocampal TrkB (C), ProBDNF (D), and P75NTR (E) levels using Western blotting. Hippocampal ProBDNF levels were upregulated only in the repeated mild traumatic brain injury group at 3 months after the second RUS. No changes in TrkB, BDNF, or P75NTR were observed at the 3-month time-point. Data in (A) and (C-E) were analyzed using two-way analysis of variance followed by two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli to correct for multiple comparisons (n = 4–6). Statistically significant discoveries versus the control group are denoted by “*”. Color image is available online.