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. 2020 Jul 13;12(1):e12069. doi: 10.1002/dad2.12069

FIGURE 3.

FIGURE 3

The effect of previous cisterna magna puncture on neurofilament light (NFL) concentration. A, The value of NFL obtained from the baseline cisterna magna puncture is plotted against the value obtained from a cisterna magna puncture performed 15 days later (n = 10, six rhesus and four cynomolgus). There is no significant change in NFL measured from repeat cisterna magna samples (P = .92, Wilcoxon rank sum test, two‐tailed). All animals were anesthetized using only ketamine. B, The median percent change in NFL for repeated lumbar punctures (14‐23 days apart) from Figure 1 is plotted next to the median percent change in NFL for repeated cisterna punctures (15 days apart). The change observed for repeated LPs is significantly greater than that observed for repeated cisterna punctures (P = .01, Mann‐Whitney U, two‐tailed).