TABLE 1.
Summary statistics for CSF biomarkers obtained from two LPs taken 14 to 23 days apart
| LP1 mean (SD)pg/mL | LP2 mean (SD)pg/mL | LP1 median (IQR)pg/mL | LP2 median (IQR)pg/mL | Mean % change(SD) | Median % change(IQR) | |
|---|---|---|---|---|---|---|
| Aβ40 | 1796.54 (772.52) | 1837.89 (678.49) | 1580.37 (977.15) | 1833.81 (1023.85) | 9.59 (39.05) | 0.72 (47.03) |
| Aβ42 | 341.59 (140.41) | 331.42 (127.28) | 314.21 (171.78) | 301.7 (143.49) | 6.18 (44.88) | −1.49 (55) |
| t‐tau | 350.63 (140.48) | 326.77 (114.66) | 338.49 (127.36) | 351.43 (120.25) | −4.9 (14.22) | −4.6 (19.74) |
| p‐tau | 42.32 (16.12) | 42.21 (12.68) | 40.87 (21.36) | 40.51 (16.36) | 3.74 (21.20) | −6.02 (26.69) |
| NFL | 419.27 (210.36) | 1586.95 (1878.25) | 369 (216.75) | 888.5 (979) | 347.74 (617.28) | 162.19 (238.88) |
Abbreviations: Aβ, amyloid beta; CSF, cerebrospinal fluid; IQR, interquartile range; LP, lumbar puncture; NFL, neurofilament light; SD, standard deviation.