Table 1.

Types of interstitial lung disease pathology seen in primary antibody deficiency

Pathology	Characteristics
Follicular bronchiolitis	Benign lymphoid hyperplasia bordering the airways
Lymphocytic interstitial pneumonia (LIP)	Pulmonary lymphoid hyperplasia involving lung interstitium with expansion of alveoli septa. Considered progression of follicular bronchiolitis. Granulomas may be present.
Nodular lymphoid hyperplasia	Well-demarcated lymphoid follicles considered a precursor to mucosal-associated lymphoid tissue (MALT) lymphoma
Non-necrotizing granulomatous inflammation	Inflammation containing circumscribed macrophages lacking a central area of necrosis
Organizing pneumonia	Production of granulation tissue within the alveolar space in response to lung injury. Formerly called bronchiolitis obliterans with organizing pneumonia or BOOP.
Granulomatous-lymphocytic interstitial lung disease (GLILD)	Broadly encompassing term typically implying the presence of granulomatous inflammation together with pulmonary lymphoid hyperplasia and sometimes also organizing pneumonia