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. 2020 Jul 10;11:395. doi: 10.3389/fendo.2020.00395

Figure 2.

Figure 2

Differential expression of circRNAs between fraction A and B asthenozoospermic derived SPZ. Differential expression of circRNAs between fraction A and B SPZ. (A) The distribution of up- and down-regulated DE-circRNAs in fraction B compared to fraction A SPZ. (B) The distribution of up- and down-regulated DE-circRNAs in the human genome, according to their host gene location. (C) Hierarchical clustering analysis of DE-circRNAs in A SPZ (samples 1A, 2A, 3A) and B SPZ (samples 1B, 2B, 3B). The expression values (Fold change ≥ 1.5, p ≤ 0.05) are represented in different colors, indicating expression levels above and below the median expression level across all samples. (D) The volcano plot was constructed using Fold-Change and p-values; in detail, the values on X and Y axes are log2 (FC = Fold-Change) and –log10 (p-values), respectively. Red points in the volcano plot represent the DE-circRNAs with statistical significance.

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