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. 2020 May 12;41(5):733–755. doi: 10.1210/endrev/bnaa015

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© Endocrine Society 2020.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 11. — Insulin detemir. A: Amino acid structure of insulin detemir. B: Mechanism of protraction: di-hexamer formation in the SC space and binding to albumin. C and D: Pharmacokinetics and PD profiles of insulin glargine (n = 12, blue line) and insulin detemir (n = 12, red line) at steady state, from euglycemic clamp study following SC injection of 0.35 U/kg in patients with type 1 diabetes. Data from Porcellati F, Rossetti P, Busciantella NR, Marzotti S, Lucidi P, Luzio S, et al. Comparison of pharmacokinetics and dynamics of the long-acting insulin analogs glargine and detemir at steady state in type 1 diabetes: a double-blind, randomized, crossover study. Diabetes Care. 2007; 30(10):2447–2452.