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Nonbioequivalent insulins. Pharmacokinetics profiles (A) and PD profiles (B) of 2 doses each of human regular U-100 and U-500 insulins from a euglycemic clamp study in 24 healthy obese subjects. Data from de la Pena A, Riddle M, Morrow LA, Jiang HH, Linnebjerg H, Scott A, et al. Pharmacokinetics and pharmacodynamics of high-dose human regular U-500 insulin versus human regular U-100 insulin in healthy obese subjects. Diabetes Care. 2011;34(12):2496–2501.
