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. 2020 May 12;41(5):733–755. doi: 10.1210/endrev/bnaa015

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© Endocrine Society 2020.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Afrezza^® inhaled insulin. A: Pharmacokinetics profile (baseline corrected serum insulin concentration) of inhaled Afrezza^® (8 units) compared to injected insulin lispro (8 units) in 12 subjects with type 1 diabetes. B: Pharmacodynamics profile of inhaled Afrezza^® (8 units) compared to injected insulin lispro (10 units) in 25 subjects with type 1 diabetes. Both studies were euglycemic clamp studies. Data from Heinemann L, Baughman R, Boss A, Hompesch M. Pharmacokinetic and pharmacodynamic properties of a novel inhaled insulin. J Diabetes Sci Technol. 2017;11(1):148–156.