Appendix 2.

Criteria for qualifying “clinical evidence of arthropathy.”

Joint	Criteria	n (%)	HFE gene status
MCP2–3#	Passive flexion <70°	11 (11.8)	- C282Y/C282Y, n = 9 - C282Y/H63D, n = 1 - H63D/H63D, n = 1 - C282Y/wt, n = 0
Radiocarpal#	Passive extension <50° or passive flexion <40°	8 (8.6)	- C282Y/C282Y, n = 5 - C282Y/H63D, n = 1 - H63D/H63D, n = 1 - C282Y/wt, n = 1
Elbow	Passive extension deficit of at least 10° or passive flexion <120°	1 (1.1)	- C282Y/C282Y, n = 0 - C282Y/H63D, n = 1 - H63D/H63D, n = 0 - C282Y/wt, n = 0
Hip	Passive flexion <100° or passive internal rotation <20°	6 (6.5)	- C282Y/C282Y, n = 5 - C282Y/H63D, n = 0 - H63D/H63D, n = 0 - C282Y/wt, n = 1
Ankle#	Passive plantar flexion <20°	1 (1.1)	- C282Y/C282Y, n = 1 - C282Y/H63D, n = 0 - H63D/H63D, n = 0 - C282Y/wt, n = 0
Any joint	Any limited range of motion	19 (20.4)	- C282Y/C282Y, n = 13 - C282Y/H63D, n = 2 - H63D/H63D, n = 2 - C282Y/wt, n = 2

^#All patients had radiographs.