TABLE 1.
Associations of four significant expression-related SNPs (eSNPs) with GC risk under the additive genetic model.
| SNP | Region | Allelesa |
NJ-GWAS |
BJ-GWAS |
SX-GWAS |
Fixed-effect meta-analysis |
||
| OR(95% CI)b | OR(95% CI)b | OR(95% CI)c | OR(95% CI) | P value | FDRd | |||
| rs6676150 | 1q22 | G/C | 0.67 (0.52–0.86) | 0.79 (0.54–1.17) | 0.55 (0.65–0.76) | 0.67 (0.59–0.76) | 4.29 × 10–10 | 3.41 × 10–6 |
| rs12217597 | 10q23.33 | T/C | 1.05 (0.85–1.29) | 1.31 (0.95–1.81) | 1.28 (1.45–1.64) | 1.33 (1.21–1.47) | 1.74 × 10–8 | 6.92 × 10–2 |
| rs836545 | 7p22.1 | C/T | 1.10 (0.91–1.33) | 1.37 (1.04–1.81) | 1.13 (1.26–1.41) | 1.23 (1.12–1.35) | 7.64 × 10–6 | 2.03 × 10–2 |
| rs1892252 | 6p22.2 | C/G | 1.69 (1.33–2.16) | 1.60 (1.05–2.43) | 0.70 (0.89–1.14) | 1.41 (1.20–1.66) | 2.43 × 10–5 | 4.83 × 10–2 |
aReference allele/effect allele. bAdjusted for age, gender, smoking, drinking and top ten principal components (PCs). cAdjusted for age, gender and top ten PCs. dFDR was corrected by Benjamini-Hochberg procedure.