TABLE 3.

Significant GC-associated protein-coding genes predicted by sequence kernel association combined test (SKAT-C).

Region	Gene	eSNP testeda	PNJ–GWAS	PBJ–GWAS	PSX–GWAS	Pcombined	FDRb
Known region
1q22	THBS3	79	4.98 × 10–2	2.75 × 10–1	7.89 × 10–6	2.65 × 10–8	3.00 × 10–5
1q22	GBA	14	2.56 × 10–2	7.14 × 10–2	8.56 × 10–4	1.29 × 10–6	1.11 × 10–3
Unknown region
3p13	GPR27	51	4.97 × 10–8	9.99 × 10–1	6.03 × 10–3	1.59 × 10–5	9.30 × 10–3
12q23.1	AMDHD1	75	1.17 × 10–6	2.83 × 10–3	1.54 × 10–1	2.65 × 10–5	1.36 × 10–2
8q22.2	FBXO43	28	3.81 × 10–1	5.00 × 10–3	1.61 × 10–3	1.26 × 10–4	4.97 × 10–2

^aNumber of eSNPs mapped to each gene. ^bFalse discovery rate in the combined dataset.